Category Archive for : ‘Completed Projects’

Molecular mechanisms of PVR (CD155) immunological pathways in viral and tumor pathogenesis

Project title: Molecular mechanisms of PVR (CD155) immunological pathways in viral and tumor pathogenesis

Grantor: Croatian Science Foundation

Grantor’s website: www.hrzz.hr

Coordinator: Prof. Dr. Tihana Lenac Roviš

Research team:

Prof. Dr. Astrid Krmpotić

Paola Kučan

Hrvoje Šimić

Antonija Miletić

Total funding: 853.000,00 HRK

Brief description:

The project is focused on the role of PVR (poliovirus receptor) which serves as a ligand for both inhibitory (TIGIT) and activating (DNAM-1 and Tactile) receptors. The evidence has been accumulated indicating the role of PVR and its receptors in immune surveillance including the control of viral infections, tumors, as well

Virus-specific Activating NK Cell Receptors and Their Viral Immunoevasion

Project title: Virus-specific Activating NK Cell Receptors and Their Viral Immunoevasion

Grantor: Croatian Science Foundation

Grantor’s website: www.hrzz.hr

Coordinator: Prof. Dr. Astrid Krmpotić

Research team:

Dr. Berislav Lisnić

Dr. Vanda Juranić Lisnić

Dr. Irena Slavuljica

Dr. Johana Julia Reichel (until November 2015)

Branka Popović

Ilija Brizić

Daria Kveštak

Jelena Železnjak

Total funding: 991.460,00 HRK

Brief description:

The infection of mice with mouse cytomegalovirus (MCMV) as a model of human CMV (HCMV) infection has been particularly informative in elucidating the role of antiviral immune response. NK cells are essential in early control of CMV infection. An evolutionary struggle between NK cells and CMVs can

Viral evasion of NK cells

Full title: Viral evasion of NK cells

Grantor: National Institutes of Health

Grant number: 1RO1AI083201-01

Grantor’s website: http://www.nih.gov/

Duration: 2009-2013

Coordinator: Stipan Jonjic, Faculty of Medicine University of Rijeka

No. of participants: 2

Partner: Prof. Dr. Joanne Trgovcich, Ohio State University, Columbus, USA

Partner web site: http://www.osu.edu/

http://www.pathology.med.ohio-state.edu/ext/Faculty_page.aspx?ID=Trgovcich

Total funding: USD 338.980

Brief description:

The human cytomegalovirus (HCMV) is a ubiquitous pathogen linked with a high risk of morbidity in immunologically suppressed and immunodeficient patients. Furthermore, HCMV is one of major viral causes of congenital infections. HCMV infections are also implicated in several chronic diseases. The strategies to

A Novel Strong CMV-promoter for Protein and RNA production

Full title: A Novel Strong CMV-promoter for Production of Proteins and Non-coding RNA molecules

Grantor: Business Innovation Center of Croatia (BICRO) – Proof of Concept (PoC) 4 Programme

Grant number: POC4_02_09

Grantor’s website:  http://www.bicro.hr/index.php?option=com_content&view=article&id=649&Itemid=554

Duration: 01 December 2012 – 30 November 2013

Coordinator: Stipan Jonjic, University of Rijeka Faculty of Medicine

No. of participants: 1

Total funding: HRK 349.380,00

  Brief description:
In every protein production system, the element called promoter determines the ultimate quantity of expressed protein. We have identified a novel region of a very strong promoter, which is

NLO

Full title: Night-of-the-Lab-Out

Grantor: FP7 Marie-Curie Action: “Researchers’ Night”

Grant number: 609815

Grantor’s website:  http://ec.europa.eu/research/mariecurieactions/                      

Duration: 1 May 2013 – 31 October 2013

Coordinator: Ana Grdovic, Agency for Mobility and EU Programmes, Croatia

No. of participants: 9

Partners:

– Drustvo Znanost.org, Croatia

– University of Split, Croatia

– University of Rijeka, Croatia

– University of Rijeka Faculty of Medicine, Croatia

– University of Rijeka Faculty of Engineering, Croatia

– University of Zagreb, Croatia

– Rudjer Boskovic Institute Zagreb, Croatia

– Institute for Physics, Zagreb, Croatia

Total funding (University of Rijeka Faculty of Medicine): EUR 2.889

Web page: http://noc-istrazivaca.hr/#naslovnica

  Brief description:
On Friday evening, September 27th, 2013, Researchers’ Night project is

CAPRI2010

Full title: The Center for Antibody Production Rijeka: Upgrading the Central Research and Service Infrastructure for the South Eastern Region of Europe

Project acronym: CAPRI2010

Grantor: European Commission: 7th Framework Programme (FP7)

Grantor’s website: http://cordis.europa.eu/fp7/

Programme: Capacities: Research potential of Convergence  regions

Programme website:http://cordis.europa.eu/fp7/capacities/convergence-regions_en.html

Duration: 2009-2012

Coordinator: Stipan Jonjic, Faculty of Medicine University of Rijeka

Total funding: EUR 619.770

Project website: http://www.capri.com.hr/capri2010.html

Brief description:

This three-year technological project should enable the Center for Proteomics to achieve self-sustainability on the long run. The key activities of CAPRI2010 consist in the establishment of new scientific collaboration in mAb development and application.

Through upgrading

The development of a model for immunotherapy of viral infections by using recombinant proteins, which connect the innate and specific immune responses

Full title: The development of a model for immunotherapy of viral infections by using recombinant proteins, which connect the innate and specific immune responses

Grantor: The National Foundation for Science, Higher Education and Technological Development of the Republic of Croatia

Grantor’s website: http://www2.nzz.hr/index.php?lang=en

Programme: Partnership in basic research

Programme website: http://www.nzz.hr/index.php?option=com_content&task=view&id=48&Itemid=104

Duration: 2008-2011

Total financing: EUR 105.000

Coordinator: Stipan Jonjic, Faculty of Medicine University of Rijeka

No. of participants: 2

Partner: Jürgen Haas, Max von-Pettenkofer Institute, Munich

Project website:

PROTEOMEBINDERS

Full title: A European Infrastructure of Ligand Binding Molecules against the Human Proteome

Grantor: European Commission: 6th Framework Programme (FP6)

Grantor’s website: http://cordis.europa.eu/fp6/

Programme: Research Infrastructures

Programme website: http://cordis.europa.eu/infrastructures/

Instrument: Coordination Action

Duration: 2006-2010

Coordinator: Mike Taussig, Babraham Bioscience Technologies, Cambridge, UK

No. of participants: 27

Partner from the Center for Proteomics: Bojan Polic, Faculty of Medicine, University of Rijeka

Project website: http://www.proteomebinders.org/

Brief description:

ProteomeBinders is a European consortium proposing to establish a comprehensive infrastructure resource of binding molecules for detection of the human proteome, together with tools for their use and applications in studying proteome function and organisation.

This 4-year FP6

The function of the NK killer receptor NKp46 in immunosurveillance of cytomegalovirus and influenza viruses

Full title: The function of the NK killer receptor NKp46 in immunosurveillance of cytomegalovirus and influenza viruses

Grantors: The Ministry of Science, Education and Sports of the Republic of Croatia & the Israel Ministry of Science, Culture and Sport

Grantors’ websites: http://public.mzos.hr/Default.aspx?sec=2428

http://www.most.gov.il/English/

Programme: Croatia-Israel Joint Research Programme

Programme websites: http://ra.haifa.ac.il/showpage.asp?Idnn=959&namef=MOST&otkuda=search.asp&order=&view

Duration: 2009-2010

Total funding (Croatian project partner – Center for Proteomics): USD 50.000

Principal Investigators: Stipan Jonjic, Faculty of Medicine University of Rijeka and Ofer Mandelboim, Hadassah Medical School, the Hebrew University Jerusalem,

A Transcriptomic Approach to Viral Disease Research

Full title: A Transcriptomic Approach to Viral Disease Research

Grantor: Unity through Knowledge Fund (UKF)

Grantor’s website: www.ukf.hr

Programme: Research Cooperability

Programme website: http://www.ukf.hr/default.aspx?id=18

Duration: 2007-2010 (36 months)

Coordinator: Joanne Trgovcich, Ohio State University, Columbus OH, USA

Partner from the Center for Proteomics: Stipan Jonjic

Total project financing (Center for Proteomics + Ohio State University): EUR 190.000

No. of participants: 2

Brief description:

Human cytomegalovirus (HCMV) is a member of beta-herpesvirus family and is widely distributed throughout world populations. After infection, which usually passes with no symptoms, it establishes a life-long persistence with minimal or