Category Archive for : ‘Completed Projects’

Full title: Biology of cytomegalovirus infection in developing brain and latency

Grantors: Croatian Science Foundation and European Social Fund

Grantor’s website: http://www.hrzz.hr/ and http://www.esf.hr/

Duration: 2020-2023

Coordinator: Dr. Ilija Brizic

Research team:
Dr. Luka Čičin Šain
Asst. Prof. Dr. Ivan Bubic dr. med.
Prof. Dr.  Ester Pernjak Pugel
Dr. Paola Kučan
Dr. Lea Hiršl
Dr. Marina Pribanic Matesic
Fran Krstanovic, mag. biokemije
Andrea Mihalic, mag. biotech. in med.

Total funding: 2.053.190,00 HRK

Brief description:
Congenital CMV infection is a major cause of trans-placentally transmitted congenital infections and may cause a wide range of structural and functional disabilities and permanent neurological sequelae such as hearing-loss, mental retardation

PROJECT TITLE: Strengthening the capacity of CerVirVac (Croatian Centre of Excellence for Virus Immunology and Vaccines) for research in viral immunology and vaccinology

FUND: European Regional Development Fund

DURATION: 01 October 2017 – 30 September 2022

COORDINATOR: University of Rijeka Faculty of Medicine

INSTITUTIONS IN THE NETWORK:
Centre for Research and Knowledge Transfer in Biotechnology of the University of Zagreb
Clinic for Infectious Diseases “Dr. Fran Mihaljevic”, Zagreb

Total value of the project: HRK 37.999.570,30 (approx. EUR 5.000.000)
The value of the EU co-financing: HRK 37.716.072,15

Brief description:

The aim of this project is to upgrade the research capacity of

Full title: Augmenting and Broadening T-cell Responses to Glioblastoma – Therapeutic Vaccine Platform Based on HCMV Expressing NKG2D Ligands

Grantors: H2020 – European Research Council (ERC) Proof of Concept Grant

Grant number:  825359

Grantor’s website:   http://erc.europa.eu/

Duration: 2018-2020

Principal investigator: Stipan Jonjic, University of Rijeka Faculty of Medicine

Total funding: 149.968,00 EUR

Brief description:

The development of an effective vaccine against human cancers is of tremendous importance. Glioblastoma multiforme (GBM) is the most malignant form of brain tumor with extremely poor survival. The human cytomegalovirus (HCMV) is involved in GBM pathogenesis suggesting that viral proteins might provide therapeutic

Full title: New Cytomegaloviral Vaccine Vector Concepts

Grantors: Helmholtz Association’s Helmholtz European Partnering Grant

Grant number:  PIE-0008

Grantor’s website:   https://www.helmholtz.de/en/

Duration: 2018-2023

Coordinator: Prof. Dr. Luka Cicin-Sain, HZI Helmholtz Centre for Infection Research

No. of participants: 6

Partners:  Prof. Dr. Stipan Jonjic, Faculty of Medicine University of Rijeka

Dr. Christine Goffinet, Charité – Universitätsmedizin Berlin

Prof. Dr. Alemka Markotic, University Hospital for Infectious Diseases (BFM) Zagreb

Prof. Dr. Stefan Pohlmann, Deutsches Primatenzentrum GmbH (DPZ), Leibniz-Institut für Primatenforschung

Prof. Dr. Albert Osterhaus Sitftung Tierärztliche Hochschule Hannover (TiHo)

Coordinator’s web site: https://www.helmholtz-hzi.de/en/

Brief description:

Numerous viruses causing vast global disease burden (e.g. HCV, HIV, and numerous emerging and re-emerging viruses)

Full title: New Approach for Development of Vaccine for Cytomegalovirus Infection

Grantors: Croatian Science Foundation

Grantor’s website:   http://www.hrzz.hr/

Duration: 2019-2022

Coordinator: Prof. Dr. Astrid Krmpotic

Research team:  doc. dr.sc. Irena Slavuljica dr. med.

                                dr. sc. Mia Cesarec

                                dr. sc. Lea Hirsl

                                dr.

Full title: NK Cells in Pathogenesis of Congenital Cytomegalovirus Infection

Grantors: Croatian Science Foundation

Grantor’s website:   http://www.hrzz.hr/

Duration: 2018-2022

Coordinator: Dr. Ilija Brizic

Research team: Prof. Dr. Ester Pernjak Pugel.

                                Prof. Dr. Jelena Tomac

                                Dr. Berislav Lisnic

                                Dr. Durdica Cekinovic Grbesa

                                Dr. Vanda Juranic Lisnic

                                Jelena Materljan, dr. med.

                                Daria Kvestak mag. biol. mol.

Inflammation and Hearing Loss Following Congenital CMV Infection 

Full title: Inflammation and Hearing Loss Following Congenital CMV Infection

Grantor: National Institutes of Health

Grant number:  1 R01 DC015980-01A1

Grantor’s website:   http://www.nih.gov/

Duration: 2017-2022

Coordinator: William J Britt, University of Alabama at Birmingham, USA

No. of participants: 3

Partners:  Stipan Jonjic, Faculty of Medicine University of Rijeka

Keiko Hirose, ST. Louis, Children’s Hospital, USA

Coordinator’s web site: http://www.uab.edu/home/

https://www.uab.edu/medicine/immunology/faculty/71-britt

Total funding (Sub-award budget): USD 229.500

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Pathogenesis of cytomegalovirus infection in the ovaries, impact on fertility and pregnancy maintenance

Project title: Pathogenesis of cytomegalovirus infection in the ovaries, impact on fertility and pregnancy maintenance

Grantor: Croatian Science Foundation

Grantor’s website: http://www.hrzz.hr/

Coordinator: Dr. Vanda Juranić Lisnić

Supporting Partners: https://gamblingaus.com

Research team:
Prof. Jelena Tomac
Mijo Golemac, MD
Daria Kveštak, MA

Marija Mazor, PhD

Total funding: 1.000.000,00 HRK

Brief description:

Human cytomegalovirus (HCMV) is a herpesvirus that infects the majority of world’s population [1], attacking numerous tissues and organs. Congenital CMV infection is the main cause of trans-placentally transmitted congenital infections of newborns with annual prevalence of 0.1

The integrated anti-HCMV/anti-GBM vaccine

Project title: The integrated anti-HCMV/anti-GBM vaccine

Program – Proof of concept for scientists is intended for financing ideas, concepts, prototypes and intellectual property protection. The emphasis is put on the technological risk, and the main criteria are market orientation and innovativeness.

Grantor: Croatian Agency for SMEs, Innovations and Investments (HAMAG-BICRO)

Grantor’s website: http://www.hamagbicro.hr/

Coordinator: Hrvoje Šimić, MD

Research team:
Suzana Malić, laboratory engineer
Prof. Dr. Stipan Jonjić
Assistant Professor Berislav Lisnić
Lea Hiršl, MA

Total funding (MEDRI): 349.776,99 HRK

Brief description:

Glioblastoma multiforme (GBM) represents the most malignant form of brain tumor. The overall survival prognosis is

GLYCOVAX – A Training Network for the Rational Design of the Next Generation of Well-Defined Glycoconjugate Vaccines

Full title: GLYCOVAX – A Training Network for the Rational Design of the Next Generation of Well-Defined Glycoconjugate Vaccines

Grantor: H2020 Marie Skłodowska- Curie ITN programme

Grant number: 675671

Grantor’s website: http://www.glycovax.eu/

Duration: 01.11.2015-31.10.2019

Coordinator: Novartis Vaccines and diagnostics S.R.L. (NVD), SIENA, Italy

Beneficiary: University of Rijeka Faculty of Medicine (MEDRI)

Total funding: EUR 3.560.797.00

Total funding (MEDRI): EUR 247.761.00

Brief description:

The project aims