Category Archive for : ‘Completed Projects’

Full title: Solving the m04 paradox: Evasion of missing-self recognition and CD8 klling by MAT uORF

Grantors: Deutsche Forschungsgemeinschaft

Grant number: 421448608

Grantors web site: https://www.dfg.de/

Duration: 2019 – 2022

Coordinators:
Prof.Dr. Stipan Jonjić,
Dr. Vanda Juranić Lisnić

Total funding: EUR 249.900,00

Description:
“Cytomegaloviruses (CMVs) possess multiple mechanisms to down-regulate the expression of MHC-I from the cell surface of infected cells. While this allows efficient evasion of CD8 T cell recognition, it renders infected cells sensitive to NK cell-mediated attack according the missing-self hypothesis. How CMVs simultaneously avoid these two defense systems remains largely unclear. Viral strategies to engage inhibitory

Full title: Augmenting and Broadening T-cell Responses to Glioblastoma – Therapeutic Vaccine Platform Based on HCMV Expressing NKG2D Ligands

Grantors: H2020 – European Research Council (ERC) Proof of Concept Grant

Grant number:  825359

Grantor’s website:   http://erc.europa.eu/

Duration: 2018-2020

Principal investigator: Stipan Jonjic, University of Rijeka Faculty of Medicine

Total funding: 149.968,00 EUR

Brief description:

The development of an effective vaccine against human cancers is of tremendous importance. Glioblastoma multiforme (GBM) is the most malignant form of brain tumor with extremely poor survival. The human cytomegalovirus (HCMV) is involved in GBM pathogenesis suggesting that viral proteins might provide therapeutic

Pathogenesis of cytomegalovirus infection in the ovaries, impact on fertility and pregnancy maintenance

Project title: Pathogenesis of cytomegalovirus infection in the ovaries, impact on fertility and pregnancy maintenance

Grantor: Croatian Science Foundation

Grantor’s website: http://www.hrzz.hr/

Coordinator: Dr. Vanda Juranić Lisnić

Research team:
Prof. Jelena Tomac
Mijo Golemac, MD
Daria Kveštak, MA

Marija Mazor, PhD

Total funding: 1.000.000,00 HRK

Brief description:

Human cytomegalovirus (HCMV) is a herpesvirus that infects the majority of world’s population [1], attacking numerous tissues and organs. Congenital CMV infection is the main cause of trans-placentally transmitted congenital infections of newborns with annual prevalence of 0.1 to 2%

The integrated anti-HCMV/anti-GBM vaccine

Project title: The integrated anti-HCMV/anti-GBM vaccine

Program – Proof of concept for scientists is intended for financing ideas, concepts, prototypes and intellectual property protection. The emphasis is put on the technological risk, and the main criteria are market orientation and innovativeness.

Grantor: Croatian Agency for SMEs, Innovations and Investments (HAMAG-BICRO)

Grantor’s website: http://www.hamagbicro.hr/

Coordinator: Hrvoje Šimić, MD

Research team:
Suzana Malić, laboratory engineer
Prof. Dr. Stipan Jonjić
Assistant Professor Berislav Lisnić
Lea Hiršl, MA

Total funding (MEDRI): 349.776,99 HRK

Brief description:

Glioblastoma multiforme (GBM) represents the most malignant form of brain tumor. The overall survival prognosis is

GLYCOVAX – A Training Network for the Rational Design of the Next Generation of Well-Defined Glycoconjugate Vaccines

Full title: GLYCOVAX – A Training Network for the Rational Design of the Next Generation of Well-Defined Glycoconjugate Vaccines

Grantor: H2020 Marie Skłodowska- Curie ITN programme

Grant number: 675671

Grantor’s website: http://www.glycovax.eu/

Duration: 01.11.2015-31.10.2019

Coordinator: Novartis Vaccines and diagnostics S.R.L. (NVD), SIENA, Italy

Beneficiary: University of Rijeka Faculty of Medicine (MEDRI)

Total funding: EUR 3.560.797.00

Total funding (MEDRI): EUR 247.761.00

Brief description:

The project aims

Becoming entrepreneurial: Knowledge transfer from the University of Rijeka Faculty of Medicine to the biotechnology business sector

General Info

Full title: Becoming entrepreneurial: Knowledge transfer from the University of Rijeka Faculty of Medicine to the biotechnology business sector

Grantor: Instrument for Pre-Accession Assistance (IPA), component III C, Science and Innovation Investment Fund (SIIF), phase II

Grant number: IPA2007/HR/16IPO/001-040517

Grantor’s website: http://siif2.com/siif/

Additional information about the programme and the Central Financing and Contracting Agency (CFCA – SAFU):  

http://www.safu.hr/hr/o-programima-eu/ipa/ipa-iii/ipa-iiic

Duration: 20 April 2013 – 19 April 2015

Coordinator: Stipan Jonjic, University of Rijeka, Faculty of Medicine

Partner: Martin Messerle, Hannover Medical School

Associates:

–

MCMV Infection of the Developing CNS: Neuroinvasion and Immune Control

Full title: MCMV Infection of the Developing CNS: Neuroinvasion and Immune Control

Grantor: National Institutes of Health

Grant number: 1R01NS065845-01 (Prime Award)

Grantor’s website: http://www.nih.gov/

Duration: 2010-2015

Coordinator: William J Britt, University of Alabama at Birmingham, USA

No. of participants: 2

Partner: Stipan Jonjic, Faculty of Medicine University of Rijeka

Coordinator’s web site: http://www.uab.edu/home/

                                            http://www.microbio.uab.edu/faculty/britt/

Total funding (Sub-award budget): USD 350.000

Brief description:

Congenital human cytomegalovirus (HCMV) infection represents an important cause of neurological damage in children and is the leading cause of non-familial hearing loss in the US. Little is understood

StAdvInn

Full title: Strengthening adaptive immunity via innate immunity: enhancing the CD8 T cell response by using the NKG2D ligand expressed in a herpesvirus vector

Grantor: FP7 – European Research Council (ERC) Advanced Grant

Grant number: 322693

Grantor’s website: http://erc.europa.eu/

Duration: 01 May 2013 – 30 April 2018

Principal investigator: Stipan Jonjic, University of Rijeka Faculty of Medicine

Total funding: EUR 1.754.897

 Brief description:

CD8+ T cells play a key role in the control of infections by intracellular pathogens. Recently, several top-notch studies provided ample evidence that NK cells are important in the regulation of CD8+ T cell response. NKG2D

Congenital CMV and CNS infection mechanisms of protective immunity 

Full title: Congenital CMV and CNS infection mechanisms of protective immunity

Grantor: National Institutes of Health

Grant number:  1R01AI089956-01A1 (Prime Award)

Grantor’s website: http://www.nih.gov/

Duration: 2011-2016

Coordinator: William J Britt, University of Alabama at Birmingham, USA

No. of participants: 4

Partners: – Stipan Jonjic, Faculty of Medicine University of Rijeka

–  Ulrich Koszinowski, Max von Pettenkofer Institute, LMU, Munich, Germany

– Michael Mach, University of Erlangen – Nurnberg, Germany

Coordinator’s web site: http://www.uab.edu/home/ 

http://www.microbio.uab.edu/faculty/britt/

Total funding (Sub-award budget): USD 530.000

Brief description:

Congenital human cytomegalovirus (HCMV) represents the most common viral infection acquired by the developing

VISTRIE

Full title: Viral Strategies of Immune Evasion

Grantor: Helmholtz Association: Helmholtz Virtual Institutes

Grant number: VH-VI-424-4

Grantor’s website: http://www.helmholtz.de/en/research/promoting_research/virtual_institutes/

Project website: http://www.helmholtz-hzi.de/

Duration: 2011-2016

Coordinator: Luka Cicin-Sain, Helmholtz Centre for Infection Research, Germany

No. of participants: 5

Partners: – Martin Messerle, Universität Hannover, Germany

– Ulrich Kalinke, Twincore, Germany

– Hartmut Hengel, Heinrich Heine Universität Düsseldorf, Germany

– Stipan Jonjic, Faculty of Medicine, University of Rijeka

Total funding (Sub-contract): EUR 400.000

  Brief description:

This virtual institute will focus on the interaction of the immune system and the viral infectious agents. The novelty of this concept is to utilize immune evasive genes as tools