Category Archive for : ‘Ongoing Projects’

Project title: Highly attenuated β-herpesvirus with potent immunomodulatory capacity as vaccine vector against SARS-CoV-2

Grantor: Croatian Science Foundation

Grantor’s website: www.hrzz.hr

Coordinator: Prof. Dr. Astrid Krmpotic

Research team:

Asst. Prof. Dr. Irena Slavuljica
Dr. Maja Cokaric Brdovcak
Dr. Lea Hirsl
Mijo Golemac, dr. med.
Tina Jenus, mag. biotech. in med.
Marko Sustic, dr. med.
Mihaela Kordun, dipl. ing. mol.

Total funding: EUR 197.200,00

Brief description:

Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), appeared in China at the end of 2019 and has rapidly increased into global pandemic and a major public health issue. COVID-19 symptoms can range from very

No more hiding CoV-2: Establishment of SARS-Cov-2 mAbeom 

Project title: No more hiding CoV-2: Establishment of SARS-Cov-2 mAbeom

Grantor: Croatian Science Foundation

Grantor’s website: www.hrzz.hr

Coordinator: Dr. Ilija Brizic

Research team:

Prof. Dr. Tihana Lenac Rovis
Prof. Dr. Alemka Markotic
Dr. Paola Kucan Brlic
Dr. Ivana Strazic Geljic
Dr. Ljerka Karleusa
Carmen Rozmanic, mag. biol. exp.
Fran Krstanovic, mag. biokemije
Andrea Mihalic. mag. biotech. in med.
Suzana Malic, med. lab. ing
Karmela Miklic, med. lab. ing.

Total funding: EUR 197.050,00

Brief description:

In late December of 2019, the coronavirus disease (COVID-19) caused by severe acute respiratory syndrome CoV-2 (SARS-CoV-2) was identified in Wuhan (China). Since then, SARS-CoV-2 has been declared

Full title: Clonal dynamics of memory CD8 T cell inflation

Grantors: Swiss – Croatian Cooperation Programme

Grantor’s website: https://www.swiss-cro.hr

Grant number: 180552

Duration: 01.02.2019 – 31.01.2022

Coordinator: Annette Oxenius, Prof. Dr., Institute of Microbiology, ETH Zurich and Astrid Krmpotić, Prof. Dr., University of Rijeka, Faculty of Medicine

Total funding: CHF 399.583,00
Total funding (MEDRI): CHF 199.050,00

Brief description:
A hallmark of immunological memory is the ability of the adaptive immune system to generate long-lived antigen-specific memory T or B cells that provide rapid protection upon a secondary infection with a similar pathogen. This is the basis for vaccination.

Full title: Biology of cytomegalovirus infection in developing brain and latency

Grantors: Croatian Science Foundation and European Social Fund

Grantor’s website: http://www.hrzz.hr/ and http://www.esf.hr/

Duration: 2020-2023

Coordinator: Dr. Ilija Brizic

Research team:
Dr. Luka Čičin Šain
Asst. Prof. Dr. Ivan Bubic dr. med.
Prof. Dr.  Ester Pernjak Pugel
Dr. Paola Kučan
Dr. Lea Hiršl
Dr. Marina Pribanic Matesic
Fran Krstanovic, mag. biokemije
Andrea Mihalic, mag. biotech. in med.

Total funding: 2.053.190,00 HRK

Brief description:
Congenital CMV infection is a major cause of trans-placentally transmitted congenital infections and may cause a wide range of structural and functional disabilities and permanent neurological sequelae such as hearing-loss, mental retardation

PROJECT TITLE: Strengthening the capacity of CerVirVac (Croatian Centre of Excellence for Virus Immunology and Vaccines) for research in viral immunology and vaccinology

FUND: European Regional Development Fund

DURATION: 01 October 2017 – 30 September 2022

COORDINATOR: University of Rijeka Faculty of Medicine

INSTITUTIONS IN THE NETWORK:
Centre for Research and Knowledge Transfer in Biotechnology of the University of Zagreb
Clinic for Infectious Diseases “Dr. Fran Mihaljevic”, Zagreb

Total value of the project: HRK 37.999.570,30 (approx. EUR 5.000.000)
The value of the EU co-financing: HRK 37.716.072,15

Brief description:

The aim of this project is to upgrade the research capacity of

Full title: New Cytomegaloviral Vaccine Vector Concepts

Grantors: Helmholtz Association’s Helmholtz European Partnering Grant

Grant number:  PIE-0008

Grantor’s website:   https://www.helmholtz.de/en/

Duration: 2018-2023

Coordinator: Prof. Dr. Luka Cicin-Sain, HZI Helmholtz Centre for Infection Research

No. of participants: 6

Partners:  Prof. Dr. Stipan Jonjic, Faculty of Medicine University of Rijeka

Dr. Christine Goffinet, Charité – Universitätsmedizin Berlin

Prof. Dr. Alemka Markotic, University Hospital for Infectious Diseases (BFM) Zagreb

Prof. Dr. Stefan Pohlmann, Deutsches Primatenzentrum GmbH (DPZ), Leibniz-Institut für Primatenforschung

Prof. Dr. Albert Osterhaus Sitftung Tierärztliche Hochschule Hannover (TiHo)

Coordinator’s web site: https://www.helmholtz-hzi.de/en/

Brief description:

Numerous viruses causing vast global disease burden (e.g. HCV, HIV, and numerous emerging and re-emerging viruses)

Full title: New Approach for Development of Vaccine for Cytomegalovirus Infection

Grantors: Croatian Science Foundation

Grantor’s website:   http://www.hrzz.hr/

Duration: 2019-2022

Coordinator: Prof. Dr. Astrid Krmpotic

Research team:  doc. dr.sc. Irena Slavuljica dr. med.

                                dr. sc. Mia Cesarec

                                dr. sc. Lea Hirsl

                                dr.

Full title: NK Cells in Pathogenesis of Congenital Cytomegalovirus Infection

Grantors: Croatian Science Foundation

Grantor’s website:   http://www.hrzz.hr/

Duration: 2018-2022

Coordinator: Dr. Ilija Brizic

Research team: Prof. Dr. Ester Pernjak Pugel.

                                Prof. Dr. Jelena Tomac

                                Dr. Berislav Lisnic

                                Dr. Durdica Cekinovic Grbesa

                                Dr. Vanda Juranic Lisnic

                                Jelena Materljan, dr. med.

                                Daria Kvestak mag. biol. mol.

Full title: Scientific Center of Excellence in Viral Immunology and Development of Vaccines

Coordinator of Center’s activities: Professor Stipan Jonjić, Head of the Department for Histology and Embryology and Center for Proteomics of the Faculty of Medicine, University of Rijeka

Website: http://zci-cervirvac.hr/en/general-information/

Brief description:

Following domestic and international selection and evaluation procedure, on 10th of November 2014 the assembly of the National Committee for Science, High Education and Technological Development of the Republic of Croatia proclaimed the founding of the Scientific Center of Excellence in Viral Immunology and Development of Vaccines.

Activities

Inflammation and Hearing Loss Following Congenital CMV Infection 

Full title: Inflammation and Hearing Loss Following Congenital CMV Infection

Grantor: National Institutes of Health

Grant number:  1 R01 DC015980-01A1

Grantor’s website:   http://www.nih.gov/

Duration: 2017-2022

Coordinator: William J Britt, University of Alabama at Birmingham, USA

No. of participants: 3

Partners:  Stipan Jonjic, Faculty of Medicine University of Rijeka

Keiko Hirose, ST. Louis, Children’s Hospital, USA

Coordinator’s web site: http://www.uab.edu/home/

https://www.uab.edu/medicine/immunology/faculty/71-britt

Total funding (Sub-award budget): USD 229.500

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