A Novel Strong CMV-promoter for Protein and RNA production (BICRO)

A Novel Strong CMV-promoter for Protein and RNA production

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Full title: A Novel Strong CMV-promoter for Production of Proteins and Non-coding RNA molecules

Grantor: Business Innovation Center of Croatia (BICRO) - Proof of Concept (PoC) 4 Programme

Grant number: POC4_02_09

Grantor's website:  http://www.bicro.hr/index.php?option=com_content&view=article&id=649&Itemid=554

Duration: 01 December 2012 - 30 November 2013

Coordinator: Stipan Jonjic, University of Rijeka Faculty of Medicine

No. of participants: 1

Total funding: HRK 349.380,00


  Brief description:

In every protein production system, the element called promoter determines the ultimate quantity of expressed protein. We have identified a novel region of a very strong promoter, which is murine cytomegalovirus-derived, and potentially stronger and more comprehensive than the currently most widely used promoter for protein production in mammalian cells. This project aims to characterize, evaluate and assess the commercial potential of our invention. In the short run, we plan to test the functionality of the optimal promoter region, analyse the market and find the optimal commercialization strategy. In the long run, we intend to develop a novel, comprehensive system for the production of proteins in mammalian cells, enhance the promoter as a main commercial product of the Center and use the promoter in the Center’s activities, for the production of proteins-antigens for generation of antibodies.